- Therapeutic Category : Antidiabetic
- CAS Number : 1029877-94-8
- Molecular Formula : C22H26FN5O6
- Molecular Weight : 475.5 g/mol
- Mesh Size : As per Customer Requirement
- Form : Tablet
- Metrochem Development Status : Commercial
Mechanism of Action:
Trelagliptin is a selective, competitive and reversible inhibitor of dipeptidyl peptidase-4 (DPP-4) (Ki=1.5 nM, dissociation t1/2= 29 min).
By specific inhibition of DDP-4 activity (IC50=1.3 nM for human recombinant ddp-4), trelagliptin prevented the degradation of incretin (GLP-1 and GIP) and prolonged half-life of active forms, resulting in release of insulin and decrease of blood glucose post prandial.
Trelagliptin was highly selective DDP-4 inhibitor, which showed >10,000 fold lower inhibitory potency against the other peptidases: DPP-8, DPP-9, DPP-II, PEP or FAPα.
Trelagliptin showed no significantly inhibition up to 10 μM in a screening against a panel of 47 enzymes and 79 receptors, ion channels and transporter in vitro.
It is a highly selective dipeptidyl peptidase-4 inhibitor that is typically used as an add on treatment when the first line treatment of metformin is not achieving the expected glycemic goals; though it has been approved for use as a first line treatment when metformin cannot be used.
Metrochem API Expertise:
Metrochem API Pvt Ltd is a leading manufacturer and supplier of Active Pharmaceutical Ingredients (APIs) through our manufacturing sites in Hyderabad and Vizag. Our API facilities have been inspected and approved by several global regulatory bodies including the US FDA, Japan PMDA, KFDA, and meet the cGMP compliance standards. Adapting quickly to the ever-evolving demands, we have emerged as one of the fastest growing organization in the pharmaceutical industry across the India. To cater our customer high volume requirements, we have dedicated each of our 6 manufacturing facilities to our 3 core product groups – APIs, Pelletization& Intermediates – reinforced by a well equipped, centralized Research & Development laboratory.
We have been successfully supplying APIs all over the globe for more than 15 years. Total reactor volume exceeds 1200 KL which includes pilot and multi-purpose units. We are capable of executing extensive API requirements for our customers. Metrochem API Pvt Ltd has an experienced team of highly skilled chemists, experienced regulatory professionals and supply chain experts, who are ready to handle your API manufacturing requirements with expert care. We also offer Contract Manufacturing, Contract Research, and Custom Synthesis services. We have a stand-alone R&D center located in Hyderabad with State-of-the-art analytical facilities and over 90 scientists.We have extensively worked on and delivered new products across a wide variety of therapeutic segments and as a company, we have built strong expertise in new product development.