Rabeprazole Sodium API&Pellet

Rabeprazole Sodium Manufacturers in India - APIs&Pellets 1

Product Description:

  • Therapeutic Category : Antiulcerative
  • CAS Number : 117976-90-6
  • Molecular Formula : C18H20N3NaO3S
  • Molecular Weight : ‎381.4 g/mol‎
  • Mesh Size : As per Customer Requirement
  • Form : Capsule, Injectable, Powder, Tablet
  • Metrochem Development Status : Commercial

Mechanism of Action

Rabeprazole Sodium belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+ , K+ ATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds. It inhibits acid transport in porcine gastric vesicles with a half-life of 90 seconds.

Indication:

ACIPHEX delayed-release tablets is a proton pump inhibitor (PPI) indicated in adults for:

  • Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD)

  • Maintenance of Healing of Erosive or Ulcerative GERD

  • Treatment of Symptomatic GERD

  • Healing of Duodenal Ulcers

  • Helicobacter pylori Eradication to Reduce Risk of Duodenal Ulcer Recurrence

  • Treatment of Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome

    In adolescent patients 12 years of age and older for:

  • Short-term Treatment of Symptomatic GERD

Metrochem API Expertise:

Metrochem API Pvt Ltd is a leading manufacturer and supplier of Active Pharmaceutical Ingredients (APIs) through our manufacturing sites in Hyderabad and Vizag. Our API facilities have been inspected and approved by several global regulatory bodies including the US FDA, Japan PMDA, KFDA, and meet the cGMP compliance standards. Adapting quickly to the ever-evolving demands, we have emerged as one of the fastest growing organization in the pharmaceutical industry across the India. To cater our customer high volume requirements, we have dedicated each of our 6 manufacturing facilities to our 3 core product groups – APIs, Pelletization& Intermediates – reinforced by a well equipped, centralized Research & Development laboratory.

We have been successfully supplying APIs all over the globe for more than 15 years. Total reactor volume exceeds 1200 KL which includes pilot and multi-purpose units. We are capable of executing extensive API requirements for our customers. Metrochem API Pvt Ltd has an experienced team of highly skilled chemists, experienced regulatory professionals and supply chain experts, who are ready to handle your API manufacturing requirements with expert care. We also offer Contract Manufacturing, Contract Research, and Custom Synthesis services. We have a stand-alone R&D center located in Hyderabad with State-of-the-art analytical facilities and over 90 scientists.We have extensively worked on and delivered new products across a wide variety of therapeutic segments and as a company, we have built strong expertise in new product development.

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