Acotiamide Hydrochloride

Acotiamide Hydrochloride

Product Description:

  • Therapeutic Category : Gastroprokinetic
  • CAS Number : 773092-05-0
  • Molecular Formula : C21H31ClN4O5S
  • Molecular Weight: 518.4 g/mol
  • Mesh Size : As per Customer Requirement
  • Form : Tablet
  • Metrochem Development Status : Commercial

Metrochem API Pvt Ltd  is one of the well-known Acotiamide Hydrochloride Manufacturers in India. We have well-defined quality policies and our products undergo strict quality check in every stage of manufacturing at our factories. Our products meet international quality standards and exports worldwide.

Mechanism of Action:

  • Acotiamide, an AChE inhibitor, enhanced acetylcholine (ACh)-induced contraction and motility of the gastric antrum and body.
  • Acotiamide inhibited human AChE with mixed pattern (Ki1= 0.61 ± 0.03 µM, Ki2 = 2.7 ± 0.2 µM, and IC50 = 3 µM) and suppressed the degradation of ACh released from cholinergic nerve terminals.
  • The AChE inhibitory effect of acotiamide almost disappeared by dialysis, which was shown to be reversible.
  • Acotiamide did not show a high affinity to the muscarinic M1, M2, M3, dopamine D2Sand serotonin 5-HT4 receptors involving in the regulation of gastrointestinal motility.


Acotiamide Hydrochloride (Acofide) is used to treat patients with dyspepsia. It helps to relieve patients with symptoms such as early satiety, after-meal bloating or nausea, and epigastric discomfort or pain. This drug works by stimulating the increased production of a neurotransmitter called acetylcholine, which increases the capacity of the motility of your intestine. You are recommended to take this medication before you have your meals. If you do not complete the course of treatment, this medical condition might recur. If you are used to smoking, it is advisable that you stop smoking.

Metrochem API Expertise:

Metrochem API Pvt Ltd is a leading manufacturer and supplier of Active Pharmaceutical Ingredients (APIs) through our manufacturing sites in Hyderabad and Vizag. Our API facilities have been inspected and approved by several global regulatory bodies including the US FDA, Japan PMDA, KFDA, and meet the cGMP compliance standards. Adapting quickly to the ever-evolving demands, we have emerged as one of the fastest growing organization in the pharmaceutical industry across the India. To cater our customer high volume requirements, we have dedicated each of our 6 manufacturing facilities to our 3 core product groups – APIs, Pelletization & Intermediates – reinforced by a well-equipped, centralized Research & Development laboratory.

We have been successfully supplying APIs all over the globe for more than 15 years. Total reactor volume exceeds 1200 KL which includes pilot and multi-purpose units. We are capable of executing extensive API requirements for our customers. Metrochem API Pvt Ltd has an experienced team of highly skilled chemists, experienced regulatory professionals and supply chain experts, who are ready to handle your API manufacturing requirements with expert care. We also offer Contract Manufacturing, Contract Research, and Custom Synthesis services. We have a stand-alone R&D center located in Hyderabad with State-of-the-art analytical facilities and over 90 scientists. We have extensively worked on and delivered new products across a wide variety of therapeutic segments and as a company, we have built strong expertise in new product development.

Close Menu